Tirzepatide (Mounjaro)

Tirzepatide is a synthetic derivative of gastric inhibitory polypeptide (GIP) that has simultaneous glucagon-like peptide-1 (GLP-1) functionality as well. This combination allows Tirzepatide (Mounjaro) to lower blood glucose levels, increase insulin sensitivity, boost feelings of satiety, and accelerate weight loss.

Tirzepatide was developed to fight type 2 diabetes, but has additionally been shown to protect the cardiovascular system and act as a potent weight loss agent.

Benefits of Tirzepatide

Decreases blood sugar
Reduces hunger
Reduces body fat

Dosage Information

Doses start at the 2.5 mg dose once weekly; after 4 weeks on the 2.5 mg dose, increase to the 5 mg dose once weekly. If higher doses are required, increase by 2.5 mg increments after at least 4 weeks at the current dose. The maximum dose is 15 mg once weekly.

Tirzepatide

Tirzepatide is a synthetic analogue of gastric inhibitory polypeptide (GIP) that was developed for its ability to stimulate insulin release and thus address both type 2 diabetes and nonalcoholic fatty liver disease. Made up of 39 amino acids, the relatively large Tirzepatide (Mounjaro) stimulates the release of insulin from the pancreas by binding to both GIP and GLP-1 (glucagon-like peptide-1) receptors. Taken over longer periods of time, Tirzepatide increases adiponectin levels by as much as 26% as well[1]. Research shows that Tirzepatide reduces feelings of hunger, lowers insulin levels, and increases insulin sensitivity. Taken together, these effects cause significant weight loss of 11 kg (25 lbs), improve glucose tolerance, decrease fat (adipose) tissue, and reduce cardiovascular risk.

What Does It Do?

Tirzepatide increases the release of insulin from the pancreas resulting in
improved glucose control. Research shows that, in individuals with Type 2 diabetes,
Tirzepatide (Mounjaro) decreases hemoglobin A1c (HbA1c) levels by 2.4% after six months. The peptide also appears to aid in weight loss, showing a dose-dependent relationship and helping individuals lose as much as 11 kg (25 lbs) over six months.

It isn’t just that Tirzepatide increases insulin release though. Research suggests that the peptide actually improves the function of pancreatic beta cells, the cells that make and
release insulin. Studies suggest that Tirzepatide may actually make beta cells more effective at processing insulin, which leads not just to increases in insulin levels in the bloodstream,
but decreased stress on the beta cells themselves. This may, in turn, help to slow the progressive nature of type 2 diabetes.

Research shows that Tirzepatide doesn’t just increase insulin levels at random though it appears to do so only in response to increased blood glucose levels. During fasting, Tirzepatide actually decreases insulin levels and thus helps to increase insulin sensitivity over time. It also decreases fasting levels of glucagon, which are thought to exacerbate hyperglycemia by interfering with hepatic glucose metabolism. Overall, these changes are a
big part of the reason Tirzepatide has a profound effect on glucose and, ultimately, HbA1c
levels.

How Does It Work?

Tirzepatide is a dual agonist of the gastric inhibitory polypeptide receptor and the glucagonlike peptide-1 receptor. Action at these receptors appears to have synergistic effects that make Tirzepatide more effective than strict GLP-1 agonists that are already approved for the treatment of type 2 diabetes. The affinity of Tirzepatide for the GIP receptor is greater than its affinity for the GLP-1 receptor.

Gastric inhibitory polypeptide, which is also referred to as the glucose-dependent insulinotropic polypeptide, is synthesized naturally in the small intestine. This polypeptide binds to the GIP receptor to inhibit gastric acid secretion and gastrin release while stimulating insulin release. The latter is the primary function of GIP-R and is the primary reason that insulin levels increase following a meal.

Glucagon-like peptide-1 receptors are found on beta cells as well as in neurons in the brain. Like GIP-R, stimulation of GLP-1R stimulates the release of insulin. Natural agonists include
glucagon and GLP1, but it has also been shown to bind nearly a dozen synthetic agonists including dulaglutide, lithium, and oxyntomodulin. Activation of GLP-1R increases both
insulin synthesis and insulin release, factors that have made it a desirable target in drug development. In the brain, GLP-1R stimulation lowers appetite.

Interestingly, stimulation of GLP-1R appears to increase beta cell density in the pancreas. GLP-1R stimulation increases expression of the anti-apoptotic bcl-2 gene while reducing expression of pro-apoptotic bax and caspase-3 genes. This leads to enhanced beta cell survival and, ultimately, to increased levels of insulin.

The combination of GIPR and GLP-1R activity is what gives Tirzepatide an edge over strict GLP-1R agonists. Research shows that Tirzepatide acts identically to GIP at the GIPR, but favors cAMP production over β-arrestin recruitment when acting at the GLP-1R. These details may seem esoteric to some extent, but this difference in activity from endogenous GLP-1 appears to cause GLP-1R activation without increasing physiological internalization of the receptor. The net result is enhanced GLP-1R activity with Tarazepide compared to both endogenous GLP-1 as well as other synthetic GLP-1R agonists. These slight alterations mean that Tirzepatide drastically enhances insulin secretion, promotes feelings of satiety, and reduces inflammation in adipose tissue. These combined effects make it a highly efficacious anti-diabetes peptide.

Finally, Tirzepatide appears to alter adiponectin levels, raising overall levels of the fat-burning peptide. Increased levels of adiponectin reduce fat cell differentiation and increase energy
expenditure by making mitochondria more inefficient. A low level of this peptide hormone has been implicated in diseases such as type 2 diabetes, atherosclerosis, and non-alcoholic fatty liver disease. It is worth noting that elevated adiponectin levels elevate insulin sensitivity, so it would appear that Tirzepatide modulates insulin sensitivity via several mechanisms.

Tirzepatide and Hunger

Research shows that Tirzepatide delays gastric emptying during the earliest phases of its administration but that the effect diminishes over time as a result of tachyphylaxis. These effects are similar to those seen with pure GLP-1R agonists, indicating that this action of Tirzepatide is almost completely controlled by its GLP-1 activity and not at all by its GIP activity. It appears that the effects of Tirzepatide on gastric emptying can be prolonged if the peptide is taken at a low dose for four weeks and then the dose is escalated. This also helps to mitigate side effects caused by the peptide and creates a veritable win-win for patients.
Delayed gastric emptying can help to increase feelings of satiety and reduce hunger as well as food cravings. Combined with the effects Tirzepatide has on glucose levels, this can actually help to alter eating patterns over the long term.

Tirzepatide and Weight

As noted above, Tirzepatide use is associated with substantial weight loss over a six-month time interval. A comparison of Tirzepatide to other GLP-1 analogues, like degludoc, indicates a striking difference. Whereas Tirzepatide causes a dose-dependent decrease in weight over time, degludoc and other GLP-1R agonists cause weight gain.

It appears that the GIP agonism cause by Tirzepatide is what is responsible for the peptide’s long-term effects on weight. GIP appears to directly impact the insulin-sensitivity of adipocytes, which is likely the mechanism by which Tirzepatide impacts adiponectin levels. In short, Tirzepatide activates GIP receptors in fat cells, which then leads to an increase insulin sensitivity. This, in turn, leads to a reduction in adipose inflammation as well as an increase in adiponectin levels and the associated benefits. This isn’t the whole picture, however research shows that GIP signaling in the central nervous system regulates hypothalamic feeding centers leading to decreased food intake and improved glucose handling. This, in turn, leads to decreased body weight. Thus, it appears that Tirzepatide impacts weight via adiponectin signaling directly in adipose tissue and via CNS alterations that reduce hunger levels via GIPR signaling in the brain.

Tirzepatide and the Heart

As noted, Tirzepatide alters adiponectin levels. Low adiponectin has been associated with atherosclerosis, obesity, and heart disease while increased adiponectin levels have been associated with decrease risk of all of these things. Research in humans with type 2 diabetes has shown that Tirzepatide improves lipoprotein biomarkers, lowering levels of triglycerides, apoC-III, and a handful of other lipoproteins. Combined, these effects mean reduced risk of heart disease as a likely result of decreased adiposity. Research shows that increased adiponectin levels increase HDL levels while decreasing triglyceride levels, both of which are associated with lower risk of heart disease. The peptide hormone appears to go further though, reducing scavenger receptors in macrophages and increasing the levels of cholesterol efflux to greatly protect against atherosclerosis. Increases in adiponectin levels have been associated with improved nutrition, exercise, and the use of certain lipid-lowering medications. It appears that Tirzepatide has similar beneficial effects.

Research shows that GLP-1 is important in both the direct regulation of cardiovascular risk factors such as hypertension, dyslipidemia, and obesity as well as in the indirect regulation of risk factors like inflammation and endothelial cell dysfunction. The former effects are discussed above and below in relationship to adiponectin. The effects on inflammation and endothelial function, however, appear to be mediated more directly.

In the case of endothelial function, GLP-1 signaling has been shown to induce relaxation of blood vessels leading to decreased blood pressure and enhanced end organ perfusion. This effect appears to result from increased expression of eNOS, the enzyme that generates nitric oxide and induces vascular relaxation. Interestingly, these effects appear to be enhanced in the setting of preexisting cardiovasulcar disease and diabetes.

Of course, it is well known that inflammation is directly correlated with atherosclerosis. The details are still being worked out, but GLP-1 signaling appears to decrease inflammation via a handful of mechanisms including reduced NF-κB signaling, decreased MMP-9 activity, inhibited inflammatory cytokine synthesis, and decreases in inflammatory macrophage activity. What is more, these effects appear to last as long as three months after a single dose of a GLP-1R agonist like Tirzepatide. Tirzepatide is undergoing a clinical trial to further evaluate its medium-term effects on individuals with heart failure.

Summary

Tirzepatide is a synthetic derivative of gastric inhibitory polypeptide (GIP) that has simultaneous glucagon-like peptide-1 (GLP-1) functionality as well. This combination allows Tirzepatide to lower blood glucose levels, increase insulin sensitivity, boost feelings of satiety, and accelerate weight loss. Tirzepatide was developed to fight type 2 diabetes, but has additionally been shown to protect the cardiovascular system and act as a potent weight loss agent.

Similar Products

SEMAGLUTIDE

ADIPOTIDE

SEMAGLUTIDE

Semaglutide is a derivative of the naturally occurring GLP-1, a peptide known to lower blood sugar levels and enhance insulin secretion. Research shows that Semaglutide may also improve heart, liver, and lung function while helping to slow or prevent the effects of Alzheimer’s disease.

Semaglutide has been shown to significantly decrease appetite by delaying gastric emptying and reducing intestinal motility. Glucagon-Like Peptide-1 (GLP-1) Analog Shown to Stimulate Insulin and Suppress Glucagon Secretion in a Glucose-Dependent Manner.

Semaglutide Uses

Semaglutide 5mg is a glucagon-like peptide-1 (GLP-1) receptor agonist. It stimulates the release of insulin and suppresses the release of glucagon, typically also resulting in dramatic fat loss. Semaglutide has been studied for its potential in vitro use.

One area of interest for semaglutide in vitro studies is its potential to stimulate the production of insulin in pancreatic beta cells. Researchers investigated the effects of Semaglutide on isolated human islets, which are clusters of cells in the pancreas that produce insulin.

The researchers found that Semaglutide increased the production of insulin in response to glucose stimulation. Semaglutide also increased the expression of genes involved in insulin production and secretion, suggesting that it may have potential as a therapy for type 2 diabetes, and it typically induces marked fat loss in those who use it.

The researchers found that semaglutide increased the expression of genes involved in lipid metabolism and energy expenditure in adipose tissue. Semaglutide also reduced the expression of genes involved in inflammation and adipocyte differentiation, which are processes that contribute to the development of obesity and related metabolic disorders.

Another area of interest for Semaglutide in vitro studies is in the treatment of non-alcoholic fatty liver disease (NAFLD). NAFLD is a condition in which fat accumulates in the liver, leading to inflammation and scarring.

In a study published in 2022, researchers investigated the effects of Semaglutide on liver cells in vitro. The researchers found that Semaglutide reduced liver fat accumulation and improved markers of liver function, suggesting that it may have potential as a therapy for NAFLD.

While much of the research on semaglutide and cardiovascular health has been conducted in clinical settings, in vitro studies have also been used to investigate the mechanisms by which Semaglutide may improve cardiovascular outcomes.

The researchers found that Semaglutide reduced the proliferation and migration of vascular smooth muscle cells, which are processes that contribute to the development of atherosclerosis and other cardiovascular diseases. Semaglutide also reduced the production of inflammatory cytokines in vascular smooth muscle cells, suggesting that it may have anti-inflammatory effects in the blood vessels.

While in vitro studies can provide valuable insights into the potential uses of Semaglutide, combined with the fact that many physique conscious people like bodybuilders and many others have been using Semaglutide for years now with great fat loss and other results, we must emphasize that it is important to note that this product is not intended for human consumption. Further research, including animal studies, is needed to fully understand the safety and efficacy of Semaglutide for these and other conditions.

Usual Adult Dose for Weight Loss

Initial Dose Escalation Schedule:

Weeks 1 through 4: 0.25 mg subcutaneously once a week
Weeks 5 through 8: 0.5 mg subcutaneously once a week
Weeks 9 through 12: 1 mg subcutaneously once a week
Weeks 13 through 16: 1.7 mg subcutaneously once a week

Maintenance Dose:

Week 17 and onward: 2.4 mg subcutaneously once a week

Dosing Considerations:

If dose escalation is not tolerated, consider delaying dose escalation for 4 weeks
If the maintenance dose of 2.4 mg once a week is not tolerated, the dose can be temporarily decreased to 1.7 mg once a week for a maximum of 4 weeks
After 4 weeks, increase dose back to 2.4 mg once a week; discontinue therapy if the patient cannot tolerate the maintenance dose of 2.4 mg once a week

Comments:

For patients with type 2 diabetes, blood glucose should be monitored at baseline and during treatment.
This drug should not be coadministered with other semaglutide-containing products or with any other GLP-1 receptor agonist.
The safety and effectiveness of using this drug in combination with other weight loss products have not been established.
This drug has not been studied in patients with a history of pancreatitis.

Semaglutide Storage

Lyophilized Semaglutide is Stable at room
Temperature for 90 days, however it is best to store
in a freezer below – 8c for any extended period of time.
After reconstitution Semaglutide should be
refrigerated at temperatures not to exceed 35 F.

Conclusion

In conclusion, Semaglutide is a GLP-1 receptor agonist that has shown potential for in vitro use in the treatment of type 2 diabetes and obesity-related metabolic disorders. Further research is needed to fully understand its potential as a therapeutic agent, but in vitro studies suggest that it may be safe and effective for these and other conditions.

ADIPOTIDE

What is Adipotide?

Adipotide (a.k.a. FTPP or proapototic peptide) kills fat cells, plain and simple, by targeting the blood supply of those cells. Interestingly, adipotide is able to discern the blood vessels in fat cells from the blood vessels throughout the rest of the body and is therefore highly selective. Research in monkeys shows that adipotide not only causes weight loss, it actually boosts insulin sensitivity and offsets some of the effects of type 2 diabetes.

Adipotide before and after

Although Adipotide has been found to be effective in weight loss it is still in the clinical stages and more testing is needed. Some side effects have been logged in trials and the main concern includes dehydration. This means it can cause small kidney lesions and if this is not treated can cause kidney failure. A lot more clinical trials on humans are required to deal with problems like this. But, thanks to those in the research industry they work tirelessly to help find new cures and treatment for all conditions and diseases. That is why companies such as Anabolica are here to serve the research trade to continue their excellent work to contribute to the medical establishment around the globe.

Will Adipotide Help You to Lose Weight?

If you want to lose weight, the peptide-like formula known as Adipotide may be exactly what you’re looking for. This peptide is classified as an experimental peptodomimetic and it was created in the USA in order to help people battle obesity. This ultra-modern weight loss treatment has been tested on rhesus monkeys. Many people believe that this peptide-like formula is the future of simple and stress-free weight loss.

Adipotide is often described as a peptide – however, it is not a peptide.

Adipotide is a peptodomimetic and it differs from a peptide in that it is made from small chains of matter (this matter is similar to protein). These chains are meant to simulate the performance of peptides. During tests, rhesus monkeys which were injected with this ultra-modern peptodomimetic decreased their overall body weight by eleven percent.

Adipotide decreased the body mass index, waist circumference and fatty deposits of lab monkeys.

How Does Adipotide Work?

Adipotide is designed for targeting specific blood vessels, supplying body fat (adipose tissue)with blood.

The process results in a shrinking on your vessels, forcing the fat cells to start
feeding on these vessels. All that mechanism leads to an apoptosis, which is a form of PCD that normally occurs in multicellular organisms. Typically, there are 2 receptors where adipotide binds: prohibitin and ANXA2. These are found in your blood vessels, and they accomplish the role of supplying your white adipose tissue.

This formula must be injected and it works by killing fat cells. When fat cells die, there is a decrease in volume within subcutaneous fat. This triggers weight loss. With Adipotide, cells are killed selectively, in a programmed fashion. They die because they are deprived of vital nutrients.

This formula works by destroying blood supply which contributes to fat cell growth. The process of targeted induction (Apoptosis), which kills cells, is the primary mechanism by which Adipotide supports weight loss. This ‘peptide’ has a couple of domains, both of which function separately in order to combat obesity.

The first domain is a homing domain and it works by targeting a membrane-associated protein which is known as Prohibitin. The homing domain works on adipose vascular endothelial cell matter. The second domain is a membrane-disrupting domain, which causes cell death by stopping or inhibiting mitochondrial membrane activity within targeted cells.

By keeping some fat cells from getting the nutrition that they need in order to stay alive, via the blood stream, this peptide-like formula provides quick weight loss results. While rhesus monkeys are the only test subjects to date, this experimental formula does hope to human subjects.

Monkeys who received Adipotide daily via injections experienced rapid and sustainable weight loss results. These test subjects lost twenty-percent of stomach fat within twenty-eight days. Some monkeys lost thirty-nine percent of their overall body fat, while others lost less. When fat cells in monkeys were killed with Adipotide, they were then metabolized by the body. Monkeys were treated with the drug for twenty-eight days and then underwent a twenty-eight day recovery period. For this reason, long-term weight loss results in rhesus monkeys are not available. However, short-term results do look promising.

Adipotide Dosing Chart

Discover the Benefits of Adipotide

As a result of the laidback lifestyle of humans as well as the contemporary work modality, it is evident that the need for practising physical activity has significantly reduced, this causes many people to become obese and overweight.

Helps you to reduce your weight in just a few months.
The process results in the loss of a certain amount of abdominal fat mass.

Adipotide contains potentiating positive effects on insulin sensitivity as it improves it drastically. It’s reflected in using insulin efficiently on your body, which has been proven to have a positive effect on decreasing on elevated levels of blood glucose.

Adipotide maintains your health, and it allows energy use from the chemical nutrients your
body is receiving.

It regulates water by removing excess water and retaining it at the appropriate time.

It processes hormones, which is useful in the regulation of BP (blood pressure).

It balances the minerals in your body, which allows the correct functionality of your body.

This formula is designed to promote weight loss and this benefit has been confirmed via pre-clinical studies. As well, it offers hope to diabetics, as studies show that it reduces side effects of diabetic health conditions. Adipotide features an innovative mechanism when compared to other therapeutics which are available in the marketplace (or which are undergoing clinical trials).

Since Adipotide works without triggering psychological symptoms, it doesn’t cause modulation of neurotransmitter matter. As well, it doesn’t have an amphetamine-type mechanism. Men and women who utilize Adipotide may therefore access benefits without a high risk of gastrointestinal side effects.

Bodybuilders Are Interested in Adipotide

Bodybuilders typically have a lot of experience with peptides and they have particular interest in this one. They know from experience that peptides are powerful formulas which allow them to change their bodies with a mind to accessing an assortment of results, from faster muscle mass growth to superior fat-burning power to optimal muscle recovery.

As well, peptides may help bodybuilders to avoid the negative side effects of anabolic steroid cycles. For this reason, many bodybuilders are interested in trying out this peptide-like formula as soon as they can. Some have already experimented with synthed versions of the formula, with mixed results. During the cutting phase of bodybuilding, when men and women need to reduce body fat without losing muscle, a formula such as Adipotide could provide practical benefits.

AOD-9604 vs SEMAGLUTIDE

AOD9604 (Growth Hormone Analogue)

AOD9604 is a peptide derived from human growth hormone (HGH) fragment 176-191, itself a derivative of human growth hormone. AOD9604 is a weight loss peptide in the truest sense of the term as it is a targeted fat burner (lipolytic) with limited additional effects. This peptide was specifically developed to maintain the lipolytic (fat burning) fragment of growth hormone without retaining any of the parent molecule’s ability to promote lean body mass accumulation. Research out of Australia shows that AOD9604 increases weight loss 3-fold compared to placebo. It affects beta-3-adrenergic receptors on white fat to boost fat breakdown and may indirectly activate apoptosis (programmed cell death) in white fat cells as well. AOD1604 is one of the most effective peptides for weight loss yet developed, with studies showing as much as a 50% reduction in weight gain over just three-weeks of administration.

This peptide is extremely safe, it is FDA approved, and there are no known health risks associated with AOD 9604 injections, especially when compared to traditional hormone-based weight loss treatments. As with any injection, some common side effects include pain, reddening, and swelling near the injection site.

Semaglutide (GLP-1 Agonist)

Semaglutide is similar in many ways to Liraglutide and is FDA approved for weight management and the treatment of metabolic syndrome. It acts as an agonist of the GLP-1 receptor. Research shows that semaglutide and similar peptides for weight loss work in two different ways. First, Semaglutide can delay gastric emptying and slow intestinal motility to increase feelings of fullness and decrease the rate of rise of blood sugar. Second, Semaglutide can act as a neurotransmitter to reduce the drive to eat in the central nervous system via reductions in the sensation of hunger as well as enhanced feelings of satiety. Semaglutide has been shown to produce a 5% weight loss over 6 months. At one year, average weight loss with semaglutide is 15% of total body weight.

You may know semaglutide as Ozempic, an injectable medication used in people with Type 2 diabetes. Ozempic can help manage blood sugar, and it can also lower the risk of heart attack and stroke if you also have heart disease. You can also find it as an oral pill, called Rybelsus. And Wegovy, a higher-strength version, is approved to help people lose weight.

Semaglutide works by mimicking a gut hormone that causes your pancreas to release insulin, blocks your liver from releasing sugar, and slows down how fast food leaves your stomach. While these actions can be beneficial for Type 2 diabetes and weight loss, they can also cause some side effects.

Some semaglutide side effects can be bothersome and make the medication difficult to tolerate. But the good news is that they usually subside over time. Although rare, there are also some serious side effects to know about. Keep reading to learn more about 10 semaglutide side effects to know about and how to manage them.

1. Nausea and vomiting

Nausea is the most common semaglutide side effect. Up to 20% of people taking it for Type 2 diabetes reported nausea in clinical trials. Nausea is even mire common if you’re taking the higher-dose version for weight loss. Vomiting tends to be less common than nausea.

You’re more likely to experience these side effects with higher doses of semaglutide. That’s why your healthcare provider will raise your dose slowly over a few weeks to minimize these effects. For most people, these side effects should improve over time as your body gets used to the medication.

Eating smaller meals, avoiding high-fat foods, and remaining upright after you eat can also help manage potential nausea and vomiting from semaglutide. But if these side effects are accompanied by severe stomach pain that may or may not spread to your back, get medical attention right away. This could be a signs of pancreatitus, a rare but serious side effect. More on that later.

2. Diarrhea

Diarrhea is another common semaglutide side effect. Around 9% of people taking it for Type 2 diabetes and 30% of people taking it for weight loss reported diarrhea during clinical trials.

Similar to nausea and vomiting, you’re more likely to experience diarrhea with higher doses of semaglutide. As mentioned above, your healthcare provider will slowly raise your dose over time to minimize this side effect. Constipation can also happen, but it tends to be less common than diarrhea.

3. Stomach pain

Mild stomach pain is another common stomach-related side effect of semaglutide. Similar to nausea, vomiting, and diarrhea, this should subside over time. Using the tips listed above can also help minimize this side effect.

Severe stomach pain can be a sign of other side effects, like pancreatitis or gallbladder problems (like gallstones). Contact your healthcare provider right away if this develops.

4. Fatigue

Fatigue is a common side effects of Wegovy, affecting 11% of people taking it in clinical trials. Fatigue was also reported in less than 5% of people taking Ozempic, and it wasn’t reported at all with Rybelsus.

Semaglutide works for weight loss by making you feel less hungry. And eating fewer calories may cause you to feel more tired. Feelings of fatigue should subside as your body adjusts to potential changes in your diet.

5. Low blood sugar

Low blood sugar (hypoglycemia) isn’t very common if you’re taking semaglutide on its own. That’s because it works by telling your body to release insulin in response to a meal specifically.

But taking semaglutide with other blood sugar-lowering medications, like insulin and sulfonylureas, raises the risk of hypoglycemia. So, your healthcare provider may need to change the dose of these medications when starting semaglutide.

If you have Type 2 diabetes, it’s important to regularly check your blood sugar levels to help avoid hypoglycemia. You may be advised to have an emergency glucagon or glucagon-like product to raise your blood sugar quickly if severe hypoglycemia happens.

6. Pancreatitis

Although rare, pancreatitis has been reported with semaglutide. If it happens, it can be life-threatening. Seek immediate medical attention if you develop severe abdominal pain, nausea and vomiting, and/or jaundice (yellowing of skin and eyes).

Let your healthcare provider know before starting semaglutide if you have a history of acute pancreatitis. They may recommend a different medication for you.

7. Gallbladder disease

Gallbladder disease, including gallstones, is possible with semaglutide, but it isn’t common. It was reported in less than 2% of people taking it in clinical trials.

Symptoms of gallbladder problems include upper stomach pain, fever, and jaundice. You may also notice clay-colored stools. Let your healthcare provider know right away if these develop.

Talk to your healthcare provider about ways you can avoid gallbladder problems while taking semaglutide. This may include dietary changes and routine physical activity.

8. Kidney damage

Studies have suggested that semaglutide may have some kidney benefits if you have Type 2 diabetes. But in rare cases, kidney damage has also been reported. This is more likely if you have severe nausea, vomiting, and/or diarrhea leading to dehydration.

Kidney damage is also more common if you already have kidney problems. Taking medications that cause you to get rid of excess water, like diuretics (water pills), also puts you at risk.

Your healthcare provider may monitor your kidneys if you’re experiencing a lot of stomach-related side effects. Let them know right away if you’re not urinating very much or at all, or notice swelling in your arms or legs.

9. Allergic reactions

Severe allergic reactions to semaglutide are rare, but possible. Call 911 or get immediate medical attention if you have swelling of the face, tongue, or throat, or shortness of breath after your dose.

Mild allergic reactions can include itching, rash, or redness at the injection site. Stopping semaglutide isn’t always necessary with mild reactions. But make sure to still tell your healthcare provider about your reaction.

Don’t use oral or injectable semaglutide if you’re allergic to any of their ingredients. And there’s a chance you could have an allergic reaction to semaglutide if you’ve had a reaction to a medication in the same class.

10. Thyroid tumors

Semaglutide has a boxed warning (the strictest warning) from the FDA about a risk of thyroid C-cell tumors. This is because animal studies found that rodents developed thyroid tumors when exposed to GLP-1 agonists. However, human studies have yet to confirm this risk.

Still, you shouldn’t take semaglutide if you or your family have a history of medullary thyroid cancer or multiple endocrine neoplasia (MEN) type 2. Contact your healthcare provider immediately if you notice signs or symptoms of thyroid cancer. These include a lump in your neck, and neck or jaw pain.

All this being said, and speaking strictly for myself (I know there will always be some who will argue to the contrary)… I personally feel it is a no-brainer which one to use if your looking for an EFFECTIVE, PROVEN and SAFE fat burning peptide… In my mind it’s AOD-9604 all the way!

Furthermore, there is a lot of evidence to back up these claims that AOD-9604 is the MUCH safer way to go. And truth be known, most of the resources I have personally checked seem to feel AOD-9604 is actually more effective than Semaglutide overall as well.

Safer… More Effective… You do the math.

I just felt it was important information to bring to you, being that these 2 peptides have gained so much attention in recent months… and these are definitely things you want to consider if you’re looking for such a product to help you with your fat loss goals.

… best of luck to you!

AOD-9064 Peptide

Try AOD-9064 Peptide if you have been in search of a peptide therapy with all of the medical weight loss benefits and none of the side effects, Peptide AOD-9604 might be the perfect treatment option for you. It has incredible success for weight loss, and is one of the very few FDA-approved peptides.

Keep reading to learn all about this beneficial peptide therapy and how you can unlock its health-hearty powers here at Anabolica.

WHAT IS PEPTIDE AOD-9604?

First and foremost, AOD-9604 Peptide is a modified form of amino acids 176-191 and was originally used as an anti-obesity drug. Once injected, this hormone derivative can stimulate the pituitary gland, which, in turn, speeds up metabolism and burns body fat.

Overall, peptide AOD 9604 greatly improves the results of dietary restrictions and exercise.

HOW DOES AOD-9604 PEPTIDE THERAPY WORK?

This FDA-approved peptide therapy has the unique ability to target areas of the body where there are abnormally high levels of fat, and works wonders when combined with exercising and consuming a lower calorie diet.

AOD-9604 Peptide has two primary methods of regulating body fat:

Stimulate lipolysis– the breakdown of fats and lipids via the hydrolyzation of triglycerides into glycerol and fatty acids.
Inhibit lipogenesis– the metabolic process that forms fat (even from nonfat foods), which increases the amount of triglycerides in the body.

Furthermore, the amino acids contained in AOD-9604 are the same as those found in the naturally occurring growth hormone (hGH).

WHO CAN BENEFIT FROM AOD-9604?

Researchers have also discovered the benefits of AOD-9604 aren’t limited to fat loss, as it also contains various other regenerative properties that may benefit people with:

Osteoarthritis
Osteoporosis
Hypercholesterolemia
Worn cartilage
Depression
Diabetes
Bone damage

One of the most notable benefits that AOD-9604 brings is the ability to help regulate blood sugar and manage insulin levels. This, in turn, will aid inflammation and weight loss. Just like growth hormone, AOD-9604 also enhances muscle-building.

IS AOD-9604 Peptide SAFE?

The U.S. Food & Drug Administration recently assigned Human GRAS status to AOD-9604, meaning it is listed under the Generally Recognized As Safe (GRAS) program. This is a designation that identifies any food additive as safe when used as intended, per the Federal Food, Drug, and Cosmetic Act.

This peptide is extremely safe and there are no known health risks associated with AOD-9064 Peptide injections, especially when compared to traditional hormone-based weight loss treatments.

As with any injection, some common side effects include pain, reddening, and swelling near the injection site. It is important to consult with your physician, or someone knowledgable, regarding medications and supplements you are currently taking for best treatment recommendations.

HOW IS AOD-9604 ADMINISTERED?

When it comes to a standard AOD-9604 treatment plan, there are two administration options:

Orally via dissolvable lozenge
Subcutaneous injection

Inject the AOD peptide about 30 minutes prior to eating to allow the peptide to fully metabolize and achieve optimal results. Usually only one injection of approx. 250-300 mcg in the morning is necessary, although some choose multiple injections daily.

It is important to follow the dosage instructions provided on the package. If you have any questions or concerns, discuss the administration of your peptide therapy with your healthcare practitioner or similarly knowledgable person.

HOW SHOULD I STORE AOD-9604?

Once the vial is open, reconstituted peptides can break down at high temperatures. Important points to consider when storing AOD-9064 Peptide include:

Store at a cool temperature ( 36 to 46°F)
Check the manufacturer’s use-by date
Take on an empty stomach

Furthermore, the injected peptide will absorb into the bloodstream much quicker when you are in a fasted state. For optimal results, consult with your doctor for the best time and dosage levels if you’re taking other medications and supplements.

WHEN WILL I SEE RESULTS?

Although results will vary depending on the person’s bio-individuality, many people will experience the full benefits of AOD-9064 Peptide within 12 weeks. Often much sooner. A range of personal attributes can affect the quality and significance of results, including:

Age
Family history
Underlying conditions
Disease Risks

The most success is typically seen in people who combine injections with a healthy diet and exercise.

Consult someone knowledgable to discuss your protocol to set you up for the ultimate success.

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TRENADROL (Dienedione)

Trenadrol (Dienedione), (estra-4,9-diene-3,17-dione)

Trenadrol (Dienedione), is a synthetic, orally active anabolic-androgenic steroid (AAS) of the 19-nortestosterone group that was never introduced for medical use. It is thought to be a prohormone of dienolone.

The drug became a controlled substance in the US on January 4, 2010, and is classified as a Schedule III anabolic steroid under the United States Controlled Substances Act. Previous to this, it was sold as a bodybuilding supplement within the United States. Prior to its scheduling, it was part of a number of supplements that were seized during FDA enforcement of Bodybuilding.com for selling unapproved new drugs. The actual active metabolite, dienolone, is almost identical to trenbolone structurally, but lacks the C11 double bond.

Average Dose:
100-200mg/day standalone
50-100mg/day when stacking
Average Cycle Length: 6-8 weeks

Characteristics
Trenadrol (Dienedione) is a non-methylated steroid that converts to a steroid known as 17b-hydroxy-estra-4,9,(10)-dien-3-one (dienolone).

Although dienedione may have some anabolic activity on its own, it gets most of its effects from conversion to dienedrone by interaction with 17b-HSD. This steroids overall effects are somewhere between trenbolone and nandrolone.

Dienedione is known for causing night sweats via its powerful thermogenic effects similar to trenbolone. This thermogenic effect makes dienedione an excellent choice for dropping bodyfat during cutting cycles.

As a 19-nor this compound has decent progestational effects which may lead to gyno symptoms, libido loss and aggressive mood swings. Part of the reason gyno may be a problem with this compound is also because it lacks androgenic potency and down-regulates DHT levels during cycle, which is the body’s natural estrogen blocker.

Dienedione does not convert to estrogen, although it can still lead to the side-effects mentioned above. Because this compound is not 17aa liver toxicity is not really a concern. However some users have reported elevated liver enzyme values during cycle, although this could be related to other factors.

Users usually experience rapid gains in strength and aggression, followed by significant weight gain after several weeks. The results are generally fairly lean with only minor bloat due to the progestational effects.

Dienedione can be used as a standalone. In an effort to prevent libido loss and gyno, it may be stacked with testosterone or one of its non-aromatizing metabolites to help keep DHT levels elevated during cycle.

Trenadrol stacks well with testosterone, growth hormone and gh secretagogues, these natural anabolics (and many other steroids and peptides)!

And while we do not encourage or discourage the use of anabolic substances or PED’s… we know many want to use them and are always looking for a safe, legitimate vendor for these products. With that in mind, we can tell you that most of the professional bodybuilders and other competition athletes we know of use one trusted supplier, and you can email them here to request their product / price list if you seek a trusted source for high quality products.

With that said, we wish you luck in your fitness endeavors. If you find you need help with any bodybuilding or fitness issues you may feel free to contact us and we will help you if we can!

Happy lifting!