The basics for building an anabolic cycle are very easy, and in my opinion should almost always include: Testosterone, HGH and possibly a third goal specific product. (Possibly more for more advanced users) I consider these the “staples” for virtually all anabolic cycles … with a few possible exceptions.
I feel it’s very important to have these anabolic cycle basics in any cycle as they are the core human hormones, and your body will assimilate and respond to them with the least chance of negative issues given that they are both natural to the human body! And there is no doubt that they can be very effective. Plus, they can be used for virtually any goal… muscle building, fat loss or body recompositioning. They will work for all!
Testosterone In Anabolic Cycle Basics
Injectable testosterone comes in many forms (esters), … common one’s include:
The above work either directly or indirectly to help bolster lagging testosterone production, but they do not work to the same efficacy as one another. In other words… it’s best to ask a knowledgeable person to find what’s best for you and YOUR situation.
Exactly which one you would use depends on your personal goals and a few other important factors. It’s best to consult with an expert to determine which will suit you and your personal goals the best.
HGH In Anabolic Cycle Basics
HGH (Human Growth Hormone) is also very important to include in your anabolic cycle basics as it too is a naturally occuring hormone within your body, thus well tolerated, and it can be highly effective for any goal (when used correctly) such as… Muscle building, fat loss or once again, body recompositioning.
There are many forms of HGH you can use, including real HGH …
… which is an HGH secretagogue, (often incorrectly labeled a Sarm) which simply means that it helps your body to secrete it’s own HGH production.
And there are many peptides which can also coax your body to perform various bodily functions, and in this case, increase HGH production … and these are:
As mentioned previously, which one you would use depends on your personal goals and a few other important factors. It’s best to consult with an expert to determine which will suit you and your personal goals the best.
Other Considerations
In addition to the two super-important items I mentioned above, there can be a strong case made to add another goal-specific anabolic to your cycle for maximum results!
The reason for this additional product is that while the above two items are helping you to reach your specific goals by maximizing success by covering both the testosterone and HGH receptor pathways… you still have other anabolic pathways that can be utilized to exponentially maximize your potential to meet your goals!
… leave them out at your own peril, because, if you do, you are leaving optimal success on the table. And in my opinion, if you are going to be working so hard at attaining your goals… busting your ass at the gym, dieting and denying yourself so many things, and dedicating your time and all of this effort.
My Thoughts
I don’t know about you… but I would want to squeak out every bit of success out of all my hard work and dedication. And that’s why this final product(s) come into play. It can help make a HUGE difference to your final results.
Now all this said, it is also important to protect your body while on any cycle and I can say without hesitation that Liver Protection is paramount. The liver does so much towards overall health and it is vital to keep it healthy and working clean throughout any cycle, and for this we always recommend the best in the business…
And there may be instances where on-cycle support of some kind such as Armidex or Cabergoline may be needed, but this is cycle specific and should be discussed with your coach or supplier to see if it is needed.
Additionally, you will ALWAYS need what is called a PCT (Post Cycle Therapy) after any anabolic cycle. PCT is designed to help you restore your natural hormone levels back to normal after your anabolic cycle… It’s a MUST!
… and often times certain peptides can also be used to help you restore natural hormone production back to optimal performance. (I find this addition helps tremendously along with the Clomid or Nolvadex) It all depends on your particular personal cycle and how you have reacted to it.
Conclusion
All of this being said … I feel it is important to always consult with an expert to make sure you are covering all of your bases and doing things right!
You certainly can make fantastic gains and get the best physique of your lifetime if everything falls into place properly… but that’s really where the rubber hits the road.
Dont let a stubborn streak or a “Mr. Know-It-All” attitude ruin what could be a great experience for yourself.
I can’t say this enough…
What To Do
It’s best to consult with a trusted expert to determine which will suit you and your personal goals the best. This is the best way to ensure that you are doing things safely and effectively, and it will also help assure your best chance at having the absolute best outcomes possible!
Growth hormone–releasing peptides, especially Ipamorelin and CJC-1295 dac have exploded in popularity among bodybuilders, biohackers, and recovery-focused athletes — and for good reason. While synthetic human growth hormone (HGH) can be effective, it’s expensive, suppressive, and banned in nearly every sport. That’s where peptides like Ipamorelin and CJC-1295 come in.
When used together, Ipamorelin and CJC-1295 form one of the most synergistic and well-tolerated stacks available. They stimulate your body’s own natural GH production — without shutting down your endocrine system or triggering wild side effects like bloating or insulin resistance.
Whether you’re looking to build lean mass, speed up recovery, improve sleep quality, or reduce signs of aging, this stack offers a smart, targeted alternative to HGH.
In this article, we’ll break down exactly how Ipamorelin and CJC-1295 work, why they’re more effective when stacked, and what to know about dosing, side effects, legality, and more.
Ipamorelin is a growth hormone–releasing peptide (GHRP) that stimulates your pituitary gland to release more natural growth hormone (GH). It works by selectively binding to the ghrelin receptor (GHS-R1a) — a key trigger in the GH release cascade.
What makes Ipamorelin unique among GHRPs like GHRP-2 and GHRP-6 is its clean side effect profile. It doesn’t spike cortisol or prolactin, doesn’t induce massive hunger, and avoids the desensitization issues seen with older GH secretagogues.
Key Features:
→ Mimics ghrelin to increase GH pulse amplitude → Does not significantly raise ACTH, prolactin, or cortisol → Very low risk of water retention, appetite spikes, or gynecomastia → Well-tolerated in both men and women
As a standalone peptide, Ipamorelin can modestly boost GH output. But when combined with a GHRH analog like CJC-1295, the effects are far more pronounced.
What Is CJC-1295 dac and How Does It Work?
CJC-1295 is a growth hormone–releasing hormone (GHRH) analog that stimulates the anterior pituitary to secrete more GH. Unlike natural GHRH, CJC-1295 has been modified to bind to albumin in the bloodstream, giving it a longer half-life and prolonged effects over several days.
When paired with a GHRP like Ipamorelin, CJC-1295 amplifies the growth hormone pulse amplitude and frequency, creating a synergistic effect greater than either peptide alone.
Key Ipamorelin and CJC-1295 dac Features:
→ Long-acting GHRH analog (half-life ~6–8 days) → Increases GH and IGF-1 production → Enhances lipolysis, muscle recovery, and tissue repair → Doesn’t suppress natural hormone production
The synergy between Ipamorelin and CJC-1295 lies in how they influence the body’s natural growth hormone (GH) release cycle. Each peptide plays a distinct role in enhancing GH production — and when stacked, they complement each other for more pronounced and sustained benefits.
➤ Amplitude + Frequency = Synergistic Growth Hormone Release
Ipamorelin acts on the ghrelin receptor (GHS-R1a) to increase the amplitude of GH pulses — meaning stronger, more concentrated releases of GH.
CJC-1295, a GHRH analog, increases the frequency of those GH pulses by stimulating the pituitary over longer durations, especially when using the DAC (Drug Affinity Complex) version for extended half-life.
When combined, they create a more natural and sustained GH secretion pattern, mimicking the body’s own pulsatile rhythm more closely than either peptide alone.
“CJC-1295 increases GH pulse frequency while Ipamorelin enhances pulse amplitude, together producing a more physiologic GH release.” — Walker et al., Endocrinology & Metabolism
➤ Why Stacking Ipamorelin with CJC-1295 dac Beats Using Either Alone
Stacking reduces suppression: Neither peptide shuts down endogenous GH production like synthetic HGH can.
Better IGF-1 optimization: The GH pulses signal the liver to naturally increase IGF-1 levels without artificial spikes.
Lower risk of desensitization: Alternating mechanisms prevent receptor fatigue or feedback inhibition.
“The Ipamorelin + CJC-1295 stack offers a balanced GH stimulation with minimal side effects or suppression, making it ideal for prolonged use.” — Miller, Journal of Peptide Science
This stack is widely considered one of the most user-friendly and effective entry points into GH-boosting peptide protocols — ideal for lifters, recovery-focused athletes, or aging individuals looking to optimize wellness.
Benefits of the Ipamorelin + CJC-1295 dac Stack
When used together, Ipamorelin and CJC-1295 create a synergistic effect that offers a wide range of performance, recovery, and aesthetic benefits. These peptides stimulate natural growth hormone pulses without shutting down your body’s own production, making them a safer and more physiological alternative to synthetic HGH or aggressive anabolics.
➤ 1. Muscle Growth and Lean Mass Retention
This peptide combo enhances IGF-1 production, which supports muscle protein synthesis and helps build and retain lean mass, especially in calorie deficits or during cutting phases.
“Increased GH and IGF-1 levels enhance nitrogen retention and lean tissue growth without significant water retention.” — Liu et al., Annals of Internal Medicine
➤ 2. Faster Recovery from Training or Injury
Growth hormone promotes tissue regeneration, collagen formation, and cellular repair. This means quicker recovery between workouts, reduced DOMS (delayed onset muscle soreness), and faster healing from strains or soft tissue injuries.
For more insights on healing-focused peptides, read BPC-157 and TB-500 for Recovery and Joint Repair.
➤ 3. Deeper, More Restorative Sleep
Users often report better sleep quality and vivid dreams, especially when peptides are dosed in the evening. Growth hormone is naturally released in deep sleep stages, and this stack may enhance that nocturnal pulse, aiding in total-body recovery.
➤ 4. Skin, Joint, and Collagen Health
GH and IGF-1 are critical for maintaining connective tissue, joint resilience, and youthful skin. Long-term users may notice:
Improved skin elasticity
Thicker, fuller hair
Stronger nails and tendons
➤ 5. Fat Loss Through Increased Lipolysis
Both peptides stimulate lipolysis, or fat breakdown, especially visceral fat. Users may see fat loss without major weight change due to simultaneous muscle gain.
IGF-1 is the main downstream mediator of GH effects, responsible for anabolism, muscle growth, and tissue repair. The Ipamorelin + CJC-1295 stack allows for consistent, non-spiked elevations in IGF-1 without the desensitization risks seen with exogenous HGH.
These combined benefits make this peptide stack an excellent option for recomposition, anti-aging, or enhanced athletic recovery — with a significantly lower risk profile than most hormonal interventions.
Dosage and Cycle Guidelines for Ipamorelin + CJC-1295 dac
Getting optimal results from your peptide stack means dialing in your dosing protocol, timing, and injection technique. While there’s no one-size-fits-all approach, clinical data and anecdotal user feedback provide a strong baseline to follow.
➤ Typical Ipamorelin and CJC-1295 dacDosing Recommendations
Ipamorelin: 100–300 mcg per dose
CJC-1295 with DAC: 1–2 mg per week (due to long half-life)
Most users inject Ipamorelin 1–2x per day and CJC-1295 1–2x per week, depending on their goal (fat loss, muscle growth, recovery, etc.).
CJC-1295 with DAC maintains elevated GH levels for up to 6–8 days, while Ipamorelin provides immediate release, making this a complementary strategy for mimicking natural GH rhythms.
➤ Timing: Morning vs Evening Injections
AM Dosing: May support fat loss and energy levels throughout the day.
PM Dosing (Pre-Bed): Tends to improve deep sleep and overnight GH pulse enhancement.
Stackers often use:
CJC-1295 (with DAC): 1 injection on Monday and Thursday
Ipamorelin: Injected once daily at night, or twice daily (AM + PM) during aggressive recovery phases
➤ Injection Method & Reconstitution
Form: Both peptides typically come in lyophilized (powder) form
Reconstitution: Mix with bacteriostatic water (1–2 mL)
Injection Site: Subcutaneous, preferably in the lower abdomen or thigh
Needle Size: 29–31 gauge insulin syringe
➤ Cycle Length Recommendations
Standard cycle: 8–12 weeks
Long-term wellness or anti-aging use: 3–6 months or continuous, with occasional breaks
Users pursuing body recomposition or post-cycle recovery often run peptides between anabolic cycles or as part of their long-term performance plan.
➤ Should You Use It With or Without Food?
Peptide injections are generally most effective when taken fasted. Wait at least:
30 minutes before eating post-injection
2 hours after your last meal for best absorption
Proper timing and consistency are key to success with this stack. Combined with a high-protein diet, training, and quality sleep, these peptides can significantly enhance recovery, fat loss, and muscle growth in a way that mimics your body’s natural rhythms.
Side Effects and Safety Profile
Compared to exogenous HGH or more aggressive peptides like GHRP-6, the Ipamorelin + CJC-1295 stack is known for its excellent safety profile. Both compounds are selective and do not overly stimulate other hormone pathways, making them a favorite for long-term use and first-time peptide users.
➤ Common Mild Side Effects
These typically appear during the first few weeks of use:
Increased hunger – Especially with Ipamorelin due to ghrelin receptor stimulation
Mild water retention – Often resolves after the body adjusts
Tingling or numbness – Usually in fingers or hands (transient)
Lightheadedness – More common with higher doses or low-carb diets
Most of these effects are dose-dependent and subside within a week or two.
“Unlike GHRP-6 or GHRP-2, Ipamorelin has minimal prolactin and cortisol elevation, which significantly reduces side effect risk.
➤ Rare or Serious Side Effects
While uncommon, some users may experience:
Insulin resistance – With long-term use or in very high doses
Carpal tunnel-like symptoms – From fluid shifts and nerve pressure
Gynecomastia – Extremely rare and usually tied to HGH abuse, not peptides
Always monitor IGF-1 levels during extended use cycles to ensure hormone levels stay within healthy ranges.
➤ Comparing to HGH Side Effects
Compound
Bloating
Insulin Resistance
Suppression
Cortisol Impact
HGH
High
Moderate–High
Yes
Neutral
Ipamorelin + CJC-1295
Low
Low
No
Neutral–Low
Compared to HGH, this peptide combo does not shut down natural GH production. It simply enhances your body’s own pulses, reducing risks like permanent suppression or hormonal imbalances.
For athletes concerned with recovery without hormonal disruption, these peptides are ideal.
Legal Status and Testing Concerns
Peptides like Ipamorelin and CJC-1295 occupy a legal gray area depending on how they’re used—and where. While they offer powerful performance and recovery benefits, it’s critical to understand their regulatory classification before starting a cycle.
➤ Research-Only Status in the U.S.
In the United States, Ipamorelin and CJC-1295 are not approved by the FDA for human consumption, meaning they are legally sold only for research purposes. However, they are widely accessible online through peptide suppliers under that disclaimer.
“Peptides such as CJC-1295 are sold for research only and are not legally sanctioned for athletic enhancement or anti-aging use.
Using these peptides personally, outside of clinical research, involves user discretion and risk.
➤ WADA/USADA Banned Status
Both CJC-1295 and Ipamorelin are listed on the World Anti-Doping Agency (WADA) Prohibited List, under the category of Peptide Hormones, Growth Factors, and Related Substances. This means:
Tested athletes (Olympic, NCAA, CrossFit, etc.) should avoid this stack entirely
These peptides are detectable in drug screens, especially CJC-1295 due to its longer half-life
Risk of suspension or disqualification if caught
➤ International Legality
Canada & UK: Research-only use permitted. Not legal for supplementation or prescribing.
Australia: Highly restricted. Classified as a Schedule 4 drug—requires prescription and registration with the TGA.
Europe: Varies by country. Generally follows the “research-use only” classification.
➤ Buying Safely
If you choose to use Ipamorelin and CJC-1295, ensure your peptide source provides:
To understand how the CJC-1295 dac and Ipamorelin stack compares to other popular growth hormone-releasing agents, here’s a breakdown of key options—including their mechanisms, benefits, and risks.
CJC-1295 + Ipamorelin is often the most well-balanced option for those seeking a natural GH pulse without major suppression or harsh side effects.
MK-677 is great for those who want to avoid injections, though it may cause water retention or hunger.
HGH provides direct hormone replacement, but comes with risks of dependency, suppression, and legal issues.
Conclusion: Is the CJC-1295 + Ipamorelin Stack Worth It?
If you’re looking for a growth hormone–boosting protocol that offers consistent, natural results without the risks of suppression or synthetic HGH dependency, the combination of CJC-1295 with DAC and Ipamorelin is one of the most effective and sustainable options available.
➤ Who It’s Ideal For
Lifters and athletes wanting better recovery, lean mass retention, and fat loss
Aging adults seeking longevity, skin elasticity, and hormonal balance
Biohackers or first-time peptide users who want results without harsh side effects
➤ Why This Stack Works
By combining CJC-1295 dac’s long-acting GH pulse frequency stimulation with Ipamorelin’s clean, selective GH amplitude increase, this stack mimics the body’s natural growth hormone secretion—providing better IGF-1 support, fat metabolism, and tissue repair than either peptide alone.
➤ Recommended Stack Additions
For enhanced results, consider adding:
DHEA → Supports hormonal balance and testosterone output
ZMT → Nighttime testosterone and recovery support with GABA, ashwagandha, and magnesium
L-Glutamine → Promotes gut health, immune resilience, and post-training recovery
This combination not only amplifies the peptide stack’s effects, but also supports overall endocrine health, muscle recovery, and deep sleep—key to optimizing performance naturally.
Next up: ➤ FAQ — Your most common questions about this peptide combo answered.
FAQ: CJC-1295 + Ipamorelin Stack
➤ Should I take it fasted or with food?
For optimal growth hormone (GH) pulse stimulation, it’s best to take Ipamorelin and CJC-1295 dac on an empty stomach, ideally 60–90 minutes after your last meal and 30 minutes before eating again. Insulin and food can blunt GH release, so fasted administration enhances efficacy.
➤ Can I stack Ipamorelin and CJC-1295 dac with MK-677 or HGH?
Yes — but with nuance.
MK-677 (Ibutamoren) is an oral GH secretagogue and can synergize with the peptide combo for maximum GH and IGF-1 output. HGH can also be used intermittently with the stack but may suppress natural GH production over time. Peptides like CJC-1295 dac + Ipamorelin are preferred for those avoiding suppression.
➤ Do I need PCT after using Ipamorelin and CJC-1295 dac?
No. Unlike anabolic steroids or SARMs, the Ipamorelin and CJC-1295 dac peptide stack does not suppress endogenous testosterone or hormone production. There’s typically no need for post cycle therapy (PCT) when using Ipamorelin and CJC-1295 responsibly.
Yes. Women often respond well to the Ipamorelin and CJC-1295 dac stack for skin health, lean mass retention, fat loss, and recovery. It avoids androgenic side effects common with anabolic steroids. Dosing may be slightly lower for women as opposed to men.
➤ How soon will I see results?
Most Ipamorelin and CJC-1295 dac users notice:
Improved sleep quality within 1–2 weeks
Better recovery and energy within 3–4 weeks
Visible changes in body composition (lean mass, skin tone, fat reduction) after 6–8 weeks of consistent use
For accelerated recovery support, consider stacking with BPC-157 or TB-500.
Hexarelin Acetate, also alternatively known as examorelin, is a small synthetic peptide that belongs to the growth hormone secretagogue class (GHS).
It is composed of just six amino acids. The chemical sequence of this growth hormone-releasing peptide (GHRP) is His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2. Being highly compact in structure makes it more stable as well as effective in terms of its functioning in the body.
The reported benefits of Hexarelin are substantial:
Stimulates Muscle Growth.
Rapid Weight Loss.
Improves Strength & Flexibility.
Faster Recovery.
Improves Sleep & Overall Well-Being.
How Does It Work
The primary function of hexarelin is to trigger the release of growth hormone from the anterior pituitary gland. Hexarelin follows multiple courses of action to achieve this purpose.
Hexarelin mimics the action of a naturally occurring hormone called ghrelin. Ghrelin is mainly synthesized in the stomach, and it travels via the bloodstream to bind with the growth hormone secretagogue receptor (GHS-R1a) located in the hippocampus.
This subsequent binding stimulates a wide array of physiological pathways such as the release of growth hormone (GH), protecting cardiomyocytes, regulating body weight, and development of the musculoskeletal system.
Hexarelin also binds with growth hormone secretagogue receptor (GHS-R1a) similar to ghrelin to initiate a phospholipid-dependent protein kinase (PKC) signaling pathway. This leads to the amplified release of growth hormone (GH) due to the coordinated action of the hypothalamus as well as the pituitary gland.
Hexarelin is also known to limit the release of somatostatin, also sometimes referred to as growth hormone-inhibiting hormone (GHIH). This leads to higher serum levels of growth hormone (GH).
The availability of growth hormone secretagogue receptor (GHS-R1a) in the peripheral organs like the heart, bones, adrenal gland, and digestive tract means that hexarelin can also trigger a localized effect. Particularly, the binding of hexarelin with cardiac receptors called CD36 is a growing area of research.
Hexarelin stimulates other endocrine pathways such as ACTH to cause the release of prolactin as well as cortisol.
Where Can I Buy It?
Being not so common, it is easy to fall into scams of buying pseudo hexarelin.
For 100% genuine product at a very reasonable price go here.
Benefits Of Hexarelin
As a growth hormone-releasing peptide (GHRP), hexarelin ensures an organic growth hormone release (GH).
It stimulates the growth of new muscle fibers. This leads to the development of lean muscle mass by bulking up muscles as well as enhancing body strength.
As hexarelin binds to the CD36 receptors located on blood cells, it greatly improves cardiovascular functioning by maintaining normal cardiac parameters such as left ventricular ejection fraction (LVEF), cardiac output, and stroke volume, and decreasing the peripheral resistance in the blood vessels.
This helps athletes meet the physical realms needed to boost their overall performance.
Hexarelin-induced release of growth hormone (GH) also burns down body fat, thereby causing weight loss.
This peptide improves overall skeletal health. This is done by making joints more flexible and making tendons, joints, and ligaments grow healthy. Hexarelin stimulates the growth of new muscle fibers. This leads to the growth of lean muscle mass by bulking up muscles as well as enhancing body strength.
This musculoskeletal growth makes the individual more resistant to injuries.
The optimal release of growth hormone due to hexarelin causes growth and proliferation around wounds and injuries so that the recovery process is quick yet effective.
Besides, it is also hypothesized to improve sleep quality to considerable levels by setting up natural sleep rhythms.
Usage in Bodybuilding
Hexarelin, like the majority of other peptides, works by promoting natural human growth hormone synthesis and release. This leads to more amino acid recruitment in the muscle fibers and increased protein synthesis, thus helping you gain muscle mass and strength.
For this purpose, the studied dose is 200-300 mcg/day. It is best to avoid eating before and after 1 hr of the peptide administration.
Is It Legal?
Check the laws of your country to determine if Hexarelin is legal or not in your area!
Who Should Use It?
Owing to the tremendous effects observed in cardiovascular health, anybody with a history of cardiovascular diseases such as myocardial infarctions and arrhythmias can take Hexarelin. This is because hexarelin is seen to minimize fibrous accumulation.
Bodybuilders aiming to build up muscles can also take Hexarelin. Anyone wishing to have a quicker recovery process can also take it.
Athletes wishing to boost their performance in their respective games can consider hexarelin usage after seeing all the benefits.
How To Use
Just like most other peptides, hexarelin is also available as a dry powder in the vial (a glass container). Once you have purchased hexarelin, you need to mix it with bacteriostatic water, depending on your dosage guidelines.
You need to inject it subcutaneously, inserting the needle just under the skin and not in the muscle. Generally, the abdominal area is seen as an ideal place to inject it. Subcutaneous injection of hexarelin is seen to achieve maximum effects on the user.
If you are afraid of needles, you can take hexarelin orally as well, with the surety of experiencing similar benefits as a subcutaneous injection.
Forms Of Hexarelin
Hormonal therapies are usually more effective in injectable forms. So, I would personally recommend taking the injectable form.
When you make a purchase, you will get a vial in which there will be hexarelin powder. The powder, once mixed with the sterile water, will give you the injectable ready form.
Surprisingly, hexarelin tablets are also available in some areas. This makes it more user-friendly as a wide variety of people can consume hexarelin. But we still highly recommend the injectable form as we know it works better.
General Dosage Guide
Being illegal in many areas means that there exist no set guidelines for the users but considering all the medical research done so far, an ideal dosage is devised.
200mcg-300mcg is advised to be the daily intake of an individual. The optimal results are often seen in people who administer hexarelin subcutaneously 2-3 times a day, with each dose comprising approximately 100 mcg.
Small administrations are often advised because this stimulates the release of growth hormone (GH) at more frequent intervals. Hence, this sets up a natural timer within a short period.
If you are taking hexarelin orally, you can take two tablets in a day, with each around 200mcg.
One of the important interpretations from existing research is that a higher dosage doesn’t seem to impact you significantly.
Cycling
To see optimal results, avoid eating anything before and after 1 hour of administration.
It is generally consumed for straight 12 to 16 weeks. Prominent benefits such as muscle building, fat loss, and quick recoveries are usually achieved during this period.
Once one cycle is complete, take a break of 25 to 30 days. You may start your new cycle for approximately 3 months to maintain the physical changes that the peptide helped you to achieve.
How To Stack
There are many possibilities for stacking Hexarelin with other substances for optinal performance and results.
The primary function of Hex is to trigger the release of growth hormone from the anterior pituitary gland. It follows multiple courses of action to achieve this purpose.
It mimics the action of a naturally occurring hormone called ghrelin. Ghrelin is mainly synthesized in the stomach, and it travels via the bloodstream to bind with the growth hormone secretagogue receptor (GHS-R1a) located in the hippocampus.
This subsequent binding stimulates a wide array of physiological pathways such as the release of growth hormone (GH), protecting cardiomyocytes, regulating body weight, and development of the musculoskeletal system.
It also binds with the growth hormone secretagogue receptor (GHS-R1a) similar to ghrelin to initiate a phospholipid-dependent protein kinase (PKC) signaling pathway. This leads to the amplified release of growth hormone (GH) due to the coordinated action of the hypothalamus as well as the pituitary gland.
It is also known to limit the release of somatostatin, also sometimes referred to as growth hormone-inhibiting hormone (GHIH). This leads to higher serum levels of growth hormone (GH).
HGH helps to maintain, build, and repair healthy tissue in the brain and other organs. This hormone can help to speed up healing after an injury and repair muscle tissue after exercise. This helps to build muscle mass, boost metabolism, and burn fat. HGH is also said to benefit the quality and appearance of the skin.
Human Growth Hormone for Bodybuilding
Human growth hormone (HGH) is associated with increased fat loss and enhanced cosmetic muscle growth. Bodybuilders may inject human growth hormone to achieve a more muscular appearance. However, most of the increase in muscle mass is actually due to fluid retention, not actual muscle growth. There are also risks associated with the use of human growth hormone.
Because of a perceived advantage to muscle growth and strength, bodybuilders and athletes who are tempted to take performance-enhancing drugs and supplements like steroids have taken HGH in order to gain an athletic advantage, or for rapid, cosmetic muscle growth.
Because HGH taken orally can be broken down by digestion, HGH is injected when used as a supplement drug. HGH is also promoted as an agent for rejuvenation for aging people who want to look and perform younger.
Side Effects
The following (but rare) side-effects of injected HGH have been reported with excessive and prolonged abuse:
Muscle or joint pain
Suppression of pituitary/hypothalamus gland function
Swelling of body tissues (edema)
Carpal tunnel syndrome (wrist nerve pain)
Elevated blood glucose levels
Expert Assessment
The National Strength and Conditioning Association (NSCA) in its 2009 review, concluded this about HGH:
“Human growth hormone increases lean body mass within weeks of administration; however, some of this change is within the water compartment and not in body cell mass. Human growth hormone is sometimes administered as a single agent, but often it is used in combination with androgens. Combined administration of HGH and resistance training is associated with maximal gains in lean body mass, muscle size, and voluntary strength in men compared with resistance exercise alone.
GHRH (growth hormone releasing hormone) is produced in the hypothalamus. Its pulsatile release from the hypothalamus triggers a pulsatile release of GH from the pituitary gland. GHRH has a very short half-life of only a few minutes (half-life = the time required to remove half of the substance from the blood. The shorter the half-life, the more rapidly the substance is removed from the body, and the less its effect on the body).
The first 29 amino acids of GHRH is the active segment. They are available as a manufactured peptide called Sermorelin. Sermorelin was further modified to increase its half-life to 30 minutes. This is called CJC 1295. CJC-1295 was further modified by adding DAC (Drug Affinity Complex) to it. DAC binds to a blood protein called albumin, which increases its half-life to 8 days. It is called CJC 1295 + DAC. CJC 1295 can also be compounded in a non-DAC form which mimics a more normal physiologic GH spike each night.
The longer half-life from the DAC binding to albumin means injections are only required once or twice per week. However, the long half-life and relatively constant blood level provide a constant stimulus for GH release from the pituitary through the GHRH receptor, which is not physiological. This can decrease the GH pulse amplitude which will result in decreased GH tissue stimulation.
CJC-1295 (DAC) Effectiveness
Chart A below shows the increase in muscle building IGF-1 that occurs from varying doses of CJC-1295 (DAC). You will note that the 250 mcg minimum dose reaches significantly higher levels and we have found that this dosing protocol works best. It is a “sweet spot” for most people if economy is a factor. It also an efficient and safe protocol! 1-2 mg per week is optimal!
Chart B above shows the large increase in IGF-1 levels over a 7 day period.
CJC-1295 (DAC) Half Life
The half life, or time it takes for the compound to be reduced to half of it’s original dose is reflected in the chart below:
This leads us to the final question…
CJC-1295 (DAC) Dosing
The sweet spot we have found with CJC-1295 (DAC) administration seems to be 1–2 mg once or twice weekly. People may think doing more would be even more beneficial, and it might, but to a limited extent. Not only are there diminishing returns from larger doses, but larger doses also increases the chance for side effects. What we have found is that 1–2 mg per week is the sweet spot before there are diminishing returns. It’s cost-effective, gives more bang for your buck, plus it decreases chance of side effects.
Use It Safely!
It is recommended when using a long-acting CJC molecule to have ‘hormone holidays’ of three months to allow the pituitary to ‘recover’. During the holidays, Sermorelin is used daily instead of CJC-1295 (DAC).
The ‘hormone holidays’ may also minimize the risk of GH resistance developing. This resistance, or insensitivity, may occur via antibodies forming that bind to and inactivate GH, or by a decreased number of GH receptors on tissues (down-regulation). These are theoretical concerns as no long-term studies have been undertaken to clarify the issues.
Side effects are rare, but may include injection site reactions (irritation, erythema, induration, pain, itching), headache, diarrhea, vasodilation (flushing, warmth, transient hypotension), nausea, abdominal pain.
Questions about this or any other peptide therapy?
You may have heard people say Somatropin is good for bodybuilding. People say the same about human growth hormone (HGH). When you hear either option mentioned people are talking about the same thing.
There is a good chance you already know this, so please forgive us for making such an obvious statement. However, many people do not know, especially those who are new to bodybuilding, so we thought we’d try to clear up the confusion right from the start.
The Benefits of Additional Growth Hormones
Human Growth Hormone is one of your primary anabolic hormones. It is responsible for much of the growth spurt you experience during your teenage years. Generally, people who exhibit higher than average growth hormone production during these years are both taller and have a higher muscle mass than others. In fact, HGH improves all of the following:
Muscle Mass
Bone Strength
Fat Reduction
Recovery
Libido
Mood
Sleep
Skin
With all those positives, it’s a shame that you get such a sharp decline of HGH by your mid-twenties. Of course, your body has reached its adult size so there is no need for such a huge amount…but more would be beneficial. Especially for muscle-builders and people wanting to burn fat more easily as well as for any of the above benefits to be honest.
Human Growth Hormone (HGH) is a peptide hormone that is known for stimulating the growth and regeneration of cells. It is a vital hormone for a person, helping to grow until becoming an adult. Then helping with a lot of different things throughout adulthood and elder ages. HGH is extremely important and is therefore prescribed to children with stunted growth. Sometimes to elder people who need to improve the quality of their life.
HGH is prescribed to adults who are suffering from HGH deficiency (which can be due to a number of reasons). In the end, HGH is extremely important, this is a protein hormone having endocrine functions in both animals and humans. Without enough HGH levels, a person cannot live a normal life having many nasty symptoms.
Since HGH is a Growth Hormone, there’s no need to mention the importance of HGH in bodybuilding.
The peptide hormone is used in the medical world for various purposes, and it is also used in the non fitness world for its anti aging properties. But is very popular in the fitness and athletic world too as a very effective (and fairly safe) performance enhancing drug.
HGH and Bodybuilding
HGH has changed the bodybuilding world. Professional bodybuilders from the 1970-1980s were about 100 lbs lighter compared to the professional bodybuilders you see competing on nowadays stages. Anabolic steroids, diets, working out – little has changed since then yet they still managed to pack on almost 100 lbs more weight. How’s that?
Human Growth Hormone has been added to the equation!
This is a compound that is capable of altering genetic limits. It makes the individual grow way more than he would ever be capable of growing without HGH.
HGH Bodybuilding Benefits
As it was earlier mentioned, HGH has a lot of benefits in bodybuilding but one of the main reasons why bodybuilders are running it is, as earlier mentioned, to positively change the genetic capability of the user.
Nonetheless, there are a lot of other benefits too such as strengthening joints and ligaments as well as healing damaged tissue. All of which are extremely important in bodybuilding where super heavy weights are present.
Another thing that HGH is appreciated for in bodybuilding is that this is a natural substance that is not very easily detectable as other performance enhancing drugs (PEDs). Nonetheless, HGH in bodybuilding is still most commonly used along with androgenic and anabolic steroids (AAS) in order to improve athletic performance and to build as many muscles as possible.
HGH in bodybuilding has lots of other benefits such as restoring back age-related deterioration of the body, that’s why it is often considered the “fountain of youth” as it is capable of turning back the biological clock of the body. That’s why it is so popular for other purposes than bodybuilding too.
But Human Growth Hormone is effective for building muscles, strengthening the immune system, reducing body fat (especially at the belly), restoring hair and skin – greatly improving their quality; normalizes blood sugar, cholesterol, increases energy, and greatly improves your sexual life too. It also does a great job in helping to heal and recover from diseases, injuries, and intense training sessions. It improves sleep quality, memory, vision and has cognitive positive effects too. There are lots of other benefits too.
HGH Bodybuilding Dosage
Human Growth Hormone is generally recommended to be administered in a dosage of 1-5 IU a day, being administered with 1 mL insulin syringe (slin pin). The total daily dose is used at the same time of the day either all at once once, or in a split dose administered 2 times daily.
People running HGH for bodybuilding purposes are usually using 4-8 IU daily as this amount is generally enough to improve body composition and grow muscles. Very often, bodybuilders add other compounds with HGH.
Some of the most common ones include Testosterone, Insulin, and many others. It could be T3, Clenbuterol, cutting steroids or bulking ones, injectables, or orals.
Sometimes, bodybuilders go to doses as high as 15 IU daily and even more. But those are dosages that are likely to offer side effects.
A normal cycle length in bodybuilding with HGH is anywhere between 5 and 8 months. But it can be run continuously with an on again, off again type cycle (ie: run M-F with Saturday and Sunday off).
HGH Bodybuilding Side Effects
HGH is taken intravenously and is usually kept in lyophilized powder. Then it is mixed with distilled bacteriostatic water when it must be injected. Is very important to keep it in the refrigerator in case you mix it to avoid side effects.
Is important to remember that HGH is only effective as an injection. HGH pills, tablets, patches, etc. are not going to increase HGH levels.
The abuse of HGH is going to lead to side effects.
Normal administrations are likely to be very well tolerated by most people, especially bodybuilders. But higher dosages are likely to offer side effects such as
carpal tunnel syndrome
increased risks of diabetes
water retention
numbness and tingling of the skin
nerve, muscle, or joint pains
there are others too
There are other side effects like sleepiness. It can interfere with the bodybuilders’ normal schedule of the day. Hypoglycemia is another side effect. Plus, if used for way too long and in way too high dosages it could lead to one of the worst HGH side effect in bodybuilding known as HGH Gut. It is seen in those bodybuilders having 8 pack abs and body fat of under 5% and still having a huge stomach. This is definitely avoidable though by simply not abusing HGH heavily for long periods.
Conclusion
In my honest opinion, if there were but one single bodybuilding (or anti-aging) product I could use for the rest of my life… it would definitely be HGH! It has the least negative side effects potential while giving the most overall benefits of any anabolic out there. The good vs bad profile of HGH is definitely vastly in favor of it being “good” compared to most any other anabolics out there… PLUS with it’s wonderful anti-aging and other benefits…. it’s pretty much a slam dunk no-brainer in my opinion… HGH is it!
