MK-677 (IBUTAMOREN)

WHAT IS MK-677 (IBUTAMOREN)?

MK-677 (also known as ibutamoren), promotes the secretion of the growth hormone (GH) and increases insulin-like growth factor 1 (IGF-1). Ibutamoren increases growth hormone levels by mimicking the action of the hormone ghrelin and binding to one of the ghrelin receptors (GHSR) in the brain.

Activated GHSR stimulates growth hormone release from the brain. Clinical studies describe only the effects ibutamoren has on appetite and as expected, like ghrelin, ibutamoren increases it. GHSR is found in brain regions that control appetite, pleasure, mood, biological rhythms, memory, and cognition.

Therefore, we can expect that ibutamoren may also affect these functions. It increases growth hormone levels with little or no increase in other hormones, such as cortisol. Cortisol suppresses the immune system, reduces wound healing, and impairs learning and memory, and it’s usually not good to have this hormone elevated.

BENEFITS OF MK-677/IBUTAMOREN

The benefits of MK-677 include muscle-building, a reduction in muscle wasting, better bone density, improved sleep, and anti-aging properties. It may also have nootropic effects and it can be beneficial in treating growth hormone deficiencies. Read on for a more in-depth look at these benefits. 

Helps Build Muscles 

Ibutamoren is frequently used as an anabolic substance, to increase lean body mass. It is orally active and can be taken once a day. MK-677 stimulates Growth Hormone and IGF-1 which each factor in significantly to maintaining lean body mass. Growth Hormone is believed by many to stimulate an increase in muscle size and strength and the ability of MK-677 to increase Growth Hormone production make it a popular choice.

One study that studied 60-year-olds indicated that injections to stimulate Growth Hormones led to increased strength in thigh muscles. When it comes to MK-677 stimulating muscle growth, its results will vary by person depending on their exercise regimen and if they have any health conditions.

In another study of 24 obese men, a two-month treatment with ibutamoren increased lean mass, and transiently increased basal metabolic rate (BMR)

Reduces Muscle Wasting

MK-677 has shown in recent studies to alleviate muscle wasting that can be caused by a decline in protein within an individual’s diet. In one study a group of healthy young adults were tested to determine if MK-677 could reverse protein catabolism and the results proved to be quite positive. As a result, MK-677 is theorized to be possibly being an effective treatment for individuals who suffer from catabolic conditions.

Increases Bone Density

Several studies have indicated that long-term use of MK-677 can have tremendous results to increase bone mineral density. This finding can benefit several populations including obese individuals, older adults, and women with menopause. These distinct populations can have detrimental health problems due to low bone mineral density and MK-677 has proven to be an effective treatment for many of them.

In 24 healthy obese male volunteers, ibutamoren increased bone turnover.

In 187 elderly adults (65 years or older), ibutamoren increased bone building, as measured by osteocalcin, a marker of bone turnover in multiple studies.

In one study with 292 post-menopausal women, ibutamoren increased bone mineral density, which helps increase bone strength and prevent osteoporosis.

The groups of people who serve to benefit by MK-677’s ability to increase bone density must research the possibility of any long-term side effects since increases in bone density typically take more than a year’s use. 

Improves Sleep

Since Growth Hormone is known to help improve sleep quality, it is commonly thought that Ibutamoren Mesylate can assist with sleep quality since it stimulates production in Growth Hormone.

A study showed that in both younger and elderly subjects, ibutamoren improved sleep quality and REM (rapid eye movement) sleep duration.

Apart from scientific studies, there have been many reports of subjective improvements in sleep quality.

Combats Aging and May Increase Longevity

As seen with other hormones in the body, Growth Hormone naturally begins a steady decline once a certain age is hit. Individuals who are aging can benefit from taking MK 677 since Growth Hormone and IGF-1 will be increased in the body among its consumption. Aging individuals who take MK 677 can improve their overall hormone profiles as they give their declining GH levels (Growth Hormone levels) a boost.  

In a study with 65 elderly men and women, daily ibutamoren increased GH and IGF-1 levels to those of healthy young adults without serious adverse effects.

In another study with 24 obese males, ibutamoren rejuvenated the growth hormone profile.

May Have Nootropic Effects

Since MK-677 shares a lot of similar qualities to Ghrelin and binds to its receptors, it is believed that MK 677 can have the same effects on the brain that Ghrelin has.

However, there are no studies that confirm whether or not MK 677 has direct nootropic effects on the brain. Scientists do have hope though that a couple of noticeable indirect methods may explain how MK 677 can be of assistance to cognitive function. Looking back at the previous section, one method that shows promise is Ibutamoren’s ability to improve sleep quality by increasing REM sleep.

Obtaining the proper amount of sleep each night is extremely important when trying to achieve adequate cognitive function. MK-677 can improve cognitive function by assisting individuals with the ability to get a good night’s rest. The ability of MK-677 to stimulate IGF-1 production can also indirectly improve cognitive function based on IGF-1’s role in cognitive function. One study indicated that IGF-1 positively affected participants’ ability to perform well on cognitive tests. We know that sleep is essential for good cognitive function.

Beneficial in Treating Growth Hormone Deficiency

Ibutamoren can increase growth hormone, IGF-1, and IGFBP-3 levels in children with growth hormone deficiency. Furthermore, these effects are achieved without changing the concentrations of prolactin, glucose, triiodothyronine (T3), thyroxine (T4), thyrotropin, cortisol or insulin.

In severely GH-deficient men, ibutamoren increased IGF-1 and growth hormone, with no significant changes in cortisol, PRL, and thyroid hormone levels. However, insulin and glucose were increased.

SIDE EFFECTS OF MK-677

MK 677 has not produced very many side effects for its users to be concerned about, but certain populations may have some side effects to look out for.

Individuals who are vulnerable to insulin sensitivity or who have Diabetes may be at risk when taking MK-677. Symptoms associated with these conditions could possibly be exacerbated by the use of MK 677. As with any other compound, correct dosing and usage of MK-677 is the key. In studies that looked at how MK-677 increases muscle mass, the dosage was key. Side effects of MK-677 are usually the result of a handful of two things: improper dosage and extended use.

Reported side effects of MK-677 are typically the result of unnaturally high levels of growth hormone in the body from taking too much too often, which include:

  • Increased appetite
  • Lethargy
  • Joint pain if you have previous medical conditions or elevated hormone levels
  • Insulin resistance
  • Possible increase in prolactin levels, which can be controlled

When dosed properly, the side effects of MK-677 are minimal to none compared to the results you get from taking it properly. 

Conclusion

MK-677 has shown to provide numerous health benefits for individuals with certain conditions. Those with low bone density, those who have trouble sleeping at night, and individuals with catabolic conditions can all benefit greatly from the use of MK 677.

The ability of the MK 677 secretagogue to effectively secrete Growth Hormone and IGF-1 proves to be a useful tool for many different populations. MK 677 has shown through numerous studies to benefit the elderly, those with obesity, have problems sleeping, have low bone density, and others. For these populations, MK 677 can be used as a helpful tool to combat issues that can be caused in large part due to a lack of Growth Hormone and IGF-1

And while we do not encourage or discourage the use of anabolic substances or PED’s… we know many want to use them and are always looking for a safe, legitimate vendor for these products. With that in mind, we can tell you that most of the professional bodybuilders and other competition athletes we know of use one trusted supplier, and you can email them here to request their product / price list if you seek a trusted source for high quality products.

With that said, we wish you luck in your fitness endeavors. If you find you need help with any bodybuilding or fitness issues you may feel free to contact us and we will help you if we can!

Happy lifting!

If you are interested in an even more IN DEPTH explanation of MK-677 and how to use it for all sorts of different personal goals you may have… click here.

GW-501516 (CARDARINE)

GW-501516 (Cardarine) Research Profile:

Anabolic activity: 3/10

Strength gains: 4/10

Fat loss / cutting: 8/10

Athletic endurance: 9/10

Description: 1st generation SARM; known as the “endurance SARM” and fat loss associated with going further and longer on same calories; slight anabolic activity for some similar to SR-9009 but longer half-life so more flexible administration.

Known for: Increasing metabolism and stamina, resulting in weight loss/cutting.

Commonly stacked with: Typical cutting stack: GW-501516, MK-2866, MK-677

Side-effects: Very few reported; one study in rats showed extreme, ultra-high doses could cause cancer, but research is not even clear on whether these reports were from people who might have already had cancer.

And while we do not encourage or discourage the use of anabolic substances or PED’s… we know many want to use them and are always looking for a safe, legitimate vendor for these products. With that in mind, we can tell you that most of the professional bodybuilders and other competition athletes we know of use one trusted supplier, and you can email them here to request their product / price list if you seek a trusted source for high quality products.

With that said, we wish you luck in your fitness endeavors. If you find you need help with any bodybuilding or fitness issues you may feel free to contact us and we will help you if we can!

Happy lifting!

S-4 (ANDARINE)

Andarine Benefits

The main benefit of S4 is its ability to help users build lean, dense muscle. This SARM is particularly useful for cutting, as well.

In fact, many recreational users have even said that Andarine is one of the best legal anabolics on the market right now, comparing it to Winstrol.

Here are some benefits of Andarine (S4):

  • Build Lean Muscle Mass
  • Increase Bone Mineral Density
  • Accelerate Body Fat Loss
  • Create “Cut And Dry” Look

Many body builders love using Andarine for the “hard and dry” look that it gives the muscles, and claim that no other SARM can do this as well.

Build Lean Muscle

One of the most obvious effects of Andarine is the rapid muscle growth that will take place shortly after your first dosage of this SARM.

Studies have shown numerous times that S-4 supports the growth of lean muscle mass, which is obviously a phenomenal health benefit to have.

In fact, many users have gained upwards of 15 pounds of muscle mass from a single cycle of Andarine, particularly if they get it from a good source.

Fat Loss for Body Building

Most people find that Andarine is a phenomenal drug to take for bodybuilding, even though it hasn’t been approved by the FDA (yet). Users find that this compound is especially helpful to retain lean muscle mass while cutting.

In addition to other supplements like creatine, whey protein, and pre-workouts, SARMs such as Andarine can drastically increase gym progress. It’s not uncommon for users to report losing 10-15 pounds of fat in just a short 4-8 week cycle using this compound.

Andarine Results

The above picture is of a user before and after a cycle of Andarine and Ostarine, and as you can see, their results are quite impressive.

Note the “hard and dry” look on the right—this is exactly why many body builders choose to take Andarine over other SARMs on the market.

Many users report Andarine results that are similar to steroids, such as losing 10-15 pounds of fat, while also gaining a 5-10 pounds of muscle.

Regardless, Andarine is an incredibly potent, muscle building SARM that is particularly good at shredding fat and getting lean during a cutting cycle.

How fast does Andarine work?

Because of its high bioavailability, the effects of Andarine S4 Sarm start to show within weeks (for some even sooner) and get better with higher doses.

Dosage & Cycles

While there is no established therapeutic medical dosage of Andarine (S4), the general consensus is that most users do well on 25-100 mg per day.

The effects are dose dependent, meaning that the more you take, the better results you will get, but the more side effects you may experience.

Here are the best Andarine dosages:

  • Beginner Dose: 25 mg per day
  • Intermediate Dose: 50 mg per day
  • Advanced Dose: 100 mg per day

Most users split their dosages up throughout the day, to maintain an even concentration in the blood, as Andarine has a 4-hour half life.

Bulking & Cutting Stacks

Some users choose to take multiple SARMs at once, called a SARMs stack—this is done to get faster results, and enhance performance even more.

Andarine is typically best used for cutting, which is why recreational users often combine it with other cutting SARMs like Cardarine or Ostarine.

Sample Bulking StackSample Cutting Stack
Andarine – 25 mg per dayAndarine – 50 mg per day
Ligandrol – 20 mg per dayCardarine – 20 mg per day
YK11 – 10 mg per dayOstarine – 25 mg per day

While Andarine (S4) is definitely more suited towards cutting, it can also be used on a bulking stack to stay lean and avoid fat buildup.

Andarine Side Effects

man on steroids with dumbbells

While there is no clinical data on the side effects of Andarine on humans, there is an ample amount of anecdotal user data we can learn from.

In addition to this, we can also assess the potential side effects of Andarine on humans by looking at the negative effects reported in animal studies.

Here are some potential side effects of Andarine:

  • Testosterone Suppression
  • Difficulty Seeing At Night
  • Mild Liver Toxicity
  • Decreased HDL Cholesterol
  • Slightly Accelerated Hair Loss

Some users may experience more side effects than others, and some may experience no side effects it all—the reports of this vary wildly.

That being said, most recreational users report that the more serious side effects go away almost immediately after ceasing Andarine usage.

Safety Guidelines

It’s best to guard your health, for both long term and short term reasons, of course—so how does one even begin to do a cycle of Andarine safely?

The most obvious thing to do first, is to start with a smaller dosage. Most beginners will do just fine on 25mg of Andarine, or even less.

Another important tip is to run a good SARMs PCT, short for post cycle therapy. This will ensure your testosterone levels get back to normal after your Andarine cycle, for optimal health and retention of your gains.

Summary

In conclusion, Andarine is a potent SARM that has very strong anabolic, muscle hardening effects, and is best used on a cutting cycle.

While it hasn’t been approved by the FDA for human use, Andarine is completely legal to buy online, for personal research purposes.

And while we do not encourage or discourage the use of anabolic substances or PED’s… we know many want to use them and are always looking for a safe, legitimate vendor for these products. With that in mind, we can tell you that most of the professional bodybuilders and other competition athletes we know of use one trusted supplier, and you can email them here to request their product / price list if you seek a trusted source for high quality products.

With that said, we wish you luck in your fitness endeavors. If you find you need help with any bodybuilding or fitness issues you may feel free to contact us and we will help you if we can!

Happy lifting!

S-23

S-23 is touted as one of the most potent and promising SARMs within bodybuilding circles. This non-steroidal compound is the drug that would help you gain muscle mass, bone strength, and joint mobility without the androgenic side effects that anabolic steroids present. S-23 is able to achieve this since it only targets certain body tissues – specific bones and muscles. In this S-23 SARM article, we will be talking about the drug in general, its benefits, side effects, S-23 results, and the ways in which it may help your cause. We will also tell you where you could buy SARM S-23 and for what price.

Benefits

S-23 presents a host of benefits. The following are some of the important ones.

• Benefits your muscles. When you’re on S-23, you would see a noticeable increase in your lean muscle mass. The compound facilitates lean muscle mass production, which means you would put on mass without any fat or water accumulation. Steroids usually help you become bigger by increasing your fat content and by retaining water.

• Increases bone strength as well. SARMs S-23 adds to bone strength by enhancing the bone mineralization process, which is how your bones become stronger. And since your muscles are growing too, there is even more bone strength.

• With increased bone strength and muscle mass, your body benefits from additional structural support which could safeguard your bones in the long run.

• It could work as a male contraceptive since it significantly brings down sperm count while you’re actively using it. It achieves this by suppressing your FSH (follicle-stimulating hormone) and LH (luteinizing hormone) levels. These hormones work in tandem to stimulate your testes to develop sperm. It’s believed that the effect is temporary, but more research needs to be done to confirm the same. Until conclusive pieces of evidence are shared, stick to your traditional contraceptive measures.

• Women, on the other hand, experience increased sexual feelings when on S-23. When women enter the menopause phase, their sex hormones take a nosedive, causing their sexual feelings and desires to plummet. If you are a woman who has been prescribed testosterone to invoke your sexual feelings, S-23 could be a safer choice.

• Helps lose fat too. Most bodybuilders and athletes administer S-23 for lean muscle mass gains or to not gain fat when bulking up. S-23 is pretty effective at increasing lean muscle mass.

• It helps bring down cholesterol levels. Reduced cholesterol levels mean a healthy heart, which is imperative when you’re training hard. S-23 works by decreasing triglyceride and bad LDL cholesterol levels in your blood. During steroid usage, these are usually quite high.

An important thing that’s worth mentioning is that the results would vary across individuals. If you really want great results from administering SARM, you must back it up with a good diet and a solid training regimen. The majority of the people who claim that S-23 did wonders for them are individuals who did not depend on S-23 alone. They used it only as a supplement – the way it should be used – and focused equally, if not more, on their diet and exercise.

This disclaimer needs to be put out because there are some people who blame S-23 or other SARMs for not doing their job when what the concerned individuals actually did was take their S-23 doses and sit on their couches waiting for their muscles to pop by themselves. Even steroidal compounds won’t work if you do not eat well or train hard enough.

If you are a newbie, you wouldn’t get optimal results or shouldn’t be expecting solid results during your initial few months on S-23. Your first couple of weeks is the time your body gets accustomed to the SARM. Once you have created the foundation and your body is at home with the SARM, you could build from there.

S-23 Side Effects

S-23

Though S-23 is highly unlikely to present you any side effects, it does offer its (minimum) share. Compared to steroids and even other SARMs, S-23 causes very few side effects. If you believe you can administer S-23 and get away with no side effects, you are wrong. And the actual dose doesn’t necessarily determine whether you get these negative effects. Even a dose as low as 5mg could lead to undesirable effects if the dosage period was a bit too long or wasn’t followed by a PCT. S-23 is quite potent and you must follow it up with a post-cycle therapy (PCT).

The lower dosages, for instance, could cause testosterone suppression. And if the dosage levels are extremely high, be ready for some major drops in your T levels. A PCT would, however, help balance things out. You could also experience certain steroid-like symptoms, such as aggression and other issues that usually accompany lower testosterone levels. However, these effects are short-term and reverse when you enter your PCT phase. With anabolic steroids, on the other hand, the effects are long-term and also irreversible in some cases.

If you’d like to steer clear of these possible side effects, it’s imperative you do not administer S-23 for prolonged time periods. Also, use good-quality PCT supplements such as Nolvadex and Clomid so that you could recover from S-23’s minor negatives as quickly as possible. Kindly note there is no substantial testing carried out on humans to ascertain the side effects S-23 may or may not cause in humans. The majority of the testing has been carried out on rats, which did not show any negative effects of S-23 dosage cycles.

S-23 Dosage

As aforementioned, clinical trials on humans have not been carried out yet. Therefore, it would be quite premature and incorrect to prescribe any particular dosage amount to humans. However, there are bodybuilders who’ve been taking S-23 for quite some time now with great results. These athletes usually recommend anywhere between 10 to 30mg a day. If you’re just starting out or it’s your very first cycle, it’s recommended you begin at the lowest dosage point. You may take it up from there once you find out how your body reacts to the dose.

Moreover, it’s fairly vital that you do not take your daily dosage amount at one go. It’s recommended you split the amount into two or three doses, with solid time gaps between subsequent dosages. For instance, if you’re doing two doses, do it once in the morning and once at night so that there’s maximum gap between the two. There is a reason why you should space your S-23 doses. S-23’s half-life is just 12 hours. This means you should strategically spread your dose out to let S-23 do its thing in your body at all times. This half-life findings, however, are based on rat studies. This means the half-life for humans could be lesser.

Anything more than 30mg a day is not recommended, even if you are a seasoned bodybuilder. This is because the jury on S-23 dosage is still out. Moreover, some existing users have claimed diminishing returns when the dosage levels are higher than 30mg. Like other users, you can always experiment with your doses. The people who were able to lock in on the right dosage amounts for themselves are the ones who tried out things. You should, therefore, consider trying things out too. There would be no harm caused even if you don’t get the optimal dosage level initially.

Though the aforementioned dosage level falls in the 10 to 30mg range, there are people who have been extremely cautious and started with 1mg. On the other side of the spectrum, there are bodybuilders who have completely gone overboard and tried 50mg or more a day. The key is to not be too overcautious or get carried away either. If you do a dose as small as 1mg, you are highly unlikely to experience anything significant from the compound, even if you do the dose for weeks together. And if you do 50mg or more, you are extremely likely to fall prey to the negative effects of overdosing. Therefore, let sense prevail and keep your dose within the recommended range.

Cycling

A critical aspect of dosing S-23 is also knowing when to stop taking it and how long to observe the abstinence. S-23 or any SARM cycle is usually up to eight weeks. The cycle is primarily employed for bulking or cutting since it assists with creating muscle mass during the bulking phase and preventing muscle wastage during the cutting cycle.

Cutting cycles could be up to eight weeks with the aforementioned dosage recommendations. You may combine this cutting cycle with other SARMs such as Ostarine, Cardarine, or Andarine. These would help lose more weight while also keeping your muscle mass intact. S-23 is particularly effective at cutting since it prevents muscle wastage when you’re experiencing a calorie deficit.

A bulking cycle with S-23 can be for the same period and with the same dosage amounts. This cycle would, however, be stacked with SARMs like RAD-140, LGD-4033, and Ibutamoren. A stack comprising multiple SARMs would help boost your gains during the cycle.

Kindly note you would also have to do post-cycle therapy (PCT) after your cutting or bulking cycle. S-23 can be quite testosterone-suppressive, which means you would have to administer some balancing supplement to get your testosterone levels back to normal again. PCT cycles are usually anywhere between four to eight weeks. Generally, it’s recommended you match your PCT phase with your bulking/cutting phase in duration. If you cannot afford to set aside an equal number of weeks, you should do at least four weeks of PCT. You may administer Nolvadex or Clomid during your PCT cycle.

S-23 stacks well with many other anabolics, but we have found it stacks especially well with Hexadrone.

Buying S23

You can request info on where to buy S-23 SARM (and other Sarms) from retailers online. There are quite a few reputable retailers out there who have SARM S-23 for sale. If you are looking to buy the best S-23 SARM, make sure you buy the drug from sellers that sell high-quality SARMs. There are a handful of them out there, ,y personal favorite being , but there are quite a few others. These sellers put up S-23 SARM for sale every now and then. Some may even offer a decent discount on your very first purchase or when you buy products in bulk. You should get a month’s supply of S-23 for around $60-$70. Based on the supplement form, the costs could go up. However, at increased price points, the concentrations would also be higher – which means a lot more bang for the buck.

Conclusion

Based on all the information available, it’s pretty safe to say that S-23 is an SARM that you could look forward to. If you are an early adopter, you may go ahead and try it out. Even if you don’t see any major improvements – in the form of decreased body fat, increased lean muscle mass, and a ripped physique – you would certainly not be bogged down by any side effects that anabolic steroids usually cause.

And while we do not encourage or discourage the use of anabolic substances or PED’s… we know many want to use them and are always looking for a safe, legitimate vendor for these products. With that in mind, we can tell you that most of the professional bodybuilders and other competition athletes we know of use one trusted supplier, and you can email them here to request their product / price list if you seek a trusted source for high quality products.

With that said, we wish you luck in your fitness endeavors. If you find you need help with any bodybuilding or fitness issues you may feel free to contact us and we will help you if we can!

Happy lifting!